Topical ivermectin improves allergic skin inflammation
E Ventre, A Rozières, V Lenief, F Albert, P Rossio… - Allergy, 2017 - Wiley Online Library
Allergy, 2017•Wiley Online Library
Background Ivermectin (IVM) is widely used in both human and veterinary medicine to treat
parasitic infections. Recent reports have suggested that IVM could also have anti‐
inflammatory properties. Methods Here, we investigated the activity of IVM in a murine model
of atopic dermatitis (AD) induced by repeated exposure to the allergen Dermatophagoides
farinae, and in standard cellular immunological assays. Results Our results show that topical
IVM improved allergic skin inflammation by reducing the priming and activation of allergen …
parasitic infections. Recent reports have suggested that IVM could also have anti‐
inflammatory properties. Methods Here, we investigated the activity of IVM in a murine model
of atopic dermatitis (AD) induced by repeated exposure to the allergen Dermatophagoides
farinae, and in standard cellular immunological assays. Results Our results show that topical
IVM improved allergic skin inflammation by reducing the priming and activation of allergen …
Background
Ivermectin (IVM) is widely used in both human and veterinary medicine to treat parasitic infections. Recent reports have suggested that IVM could also have anti‐inflammatory properties.
Methods
Here, we investigated the activity of IVM in a murine model of atopic dermatitis (AD) induced by repeated exposure to the allergen Dermatophagoides farinae, and in standard cellular immunological assays.
Results
Our results show that topical IVM improved allergic skin inflammation by reducing the priming and activation of allergen‐specific T cells, as well as the production of inflammatory cytokines. While IVM had no major impact on the functions of dendritic cells in vivo and in vitro, IVM impaired T‐cell activation, proliferation, and cytokine production following polyclonal and antigen‐specific stimulation.
Conclusion
Altogether, our results show that IVM is endowed with topical anti‐inflammatory properties that could have important applications for the treatment of T‐cell‐mediated skin inflammatory diseases.
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