Cholesterol sulfate is quantitatively the most important known sterol sulfate in human
plasma, where it is present in a concentration that overlaps that of the other abundant
circulating steroid sulfate, dehydroepiandrosterone (DHEA) sulfate. Although these
sulfolipids have similar production and metabolic clearance rates, they arise from distinct
sources and are metabolized by different pathways. While the function of DHEA sulfate
remains an enigma, cholesterol sulfate has emerged as an important regulatory molecule …