[HTML][HTML] Human follicular fluid heparan sulfate contains abundant 3-O-sulfated chains with anticoagulant activity
AI de Agostini, JC Dong, C de Vantéry Arrighi… - Journal of biological …, 2008 - ASBMB
Anticoagulant heparan sulfate proteoglycans bind and activate antithrombin by virtue of a
specific 3-O-sulfated pentasaccharide. They not only occur in the vascular wall but also in
extravascular tissues, such as the ovary, where their functions remain unknown. The rupture
of the ovarian follicle at ovulation is one of the most striking examples of tissue remodeling in
adult mammals. It involves tightly controlled inflammation, proteolysis, and fibrin deposition.
We hypothesized that ovarian heparan sulfates may modulate these processes through …
specific 3-O-sulfated pentasaccharide. They not only occur in the vascular wall but also in
extravascular tissues, such as the ovary, where their functions remain unknown. The rupture
of the ovarian follicle at ovulation is one of the most striking examples of tissue remodeling in
adult mammals. It involves tightly controlled inflammation, proteolysis, and fibrin deposition.
We hypothesized that ovarian heparan sulfates may modulate these processes through …