Ischemic heart disease secondary to coronary vascular dysfunction causes angina and
impairs quality of life and prognosis. About one-half of patients with symptoms and signs of …

The diagnostic management of patients with angina pectoris typically centres on the
detection of obstructive epicardial CAD, which aligns with evidence-based treatment options …

Angina pectoris and dyspnea in patients with normal or nonobstructive coronary vessels
remains a diagnostic challenge. Invasive coronary angiography may identify up to 60% of …

Background: Patients with angina symptoms and/or signs of ischemia but no obstructive
coronary artery disease (INOCA) pose a diagnostic and therapeutic challenge. Objectives …

Importance Coronary artery disease (CAD) and coronary microvascular dysfunction (CMD)
may contribute to the pathophysiologic characteristics of heart failure with preserved ejection …

Objectives The aim of this study was to test the hypothesis that invasive coronary function
testing at time of angiography could help stratify management of angina patients without …

Aims A fractional flow reserve (FFR) value≥ 0.90 after percutaneous coronary intervention
(PCI) is associated with a reduced risk of adverse cardiovascular events. TARGET-FFR is an …

Aims Coronary microvascular dysfunction and/or vasospasm are potential causes of
ischaemia in patients with no obstructive coronary artery disease (INOCA). We tested the …

Background: Determine the prevalence and correlates of microvascular and vasospastic
angina in patients with symptoms and signs of ischemia but no obstructive coronary artery …

Importance Microvascular obstruction commonly affects patients with acute ST-segment
elevation myocardial infarction (STEMI) and is associated with adverse outcomes. Objective …