Abstract Interleukin-1β (IL-1β)-converting enzyme cleaves the IL-1β precursor to mature IL-
1β, an important mediator of inflammation. The identification of the enzyme as a unique …

Nitric oxide (NO) conveys a variety of messages between cells, including signals for
vasorelaxation, neurotransmission, and cytotoxicity. In some endothelial cells and neurons …

VOLTAGE-DEPENDENT calcium channels mediate calcium entry into neurons, which is
crucial for many processes in the brain including synaptic transmission, dendritic spiking …

A central issue in nitric oxide (NO) research is to understand how NO can act in some
settings as a servoregulator and in others as a cytotoxin. To answer this, we have sought a …

Background The effects of less-tight versus tight control of hypertension on pregnancy
complications are unclear. Methods We performed an open, international, multicenter trial …

A typing enzyme immunoassay (TYPE-EIA) was used to determine the antigenic types of 64
astrovirus-positive specimens from nine collections from seven countries. Six of the seven …

A scoring procedure is described for measuring the quality of the results for protein
identifications obtained from spectral matching of MS/MS data using the Sequest database …

We purified three homologous antimicrobial peptides ('gallinacins') from chicken leukocytes,
examined their antimicrobial activity in vitro, and established their primary sequences by a …

Pre-mRNA introns are spliced in a macromolecular machine, the spliceosome. For each
round of splicing, the spliceosome assembles de novo in a series of ATP-dependent steps …

To determine whether clinical outcomes differed by occurrence of severe hypertension in the
international CHIPS trial (Control of Hypertension in Pregnancy Study), adjusting for the …