Medical research continues to illuminate the origins of many human diseases. Gene therapy
has been widely proposed as a novel strategy by which this knowledge can be used to …

Recent trials of intensive glycemic control suggest a possible link between hypoglycemia
and excess cardiovascular mortality in patients with type 2 diabetes. Hypoglycemia might …

It has been hypothesized that protease-activated receptors may be activated and attenuated
by more than one protease. Here, we explore a desensitization mechanism of the PAR1 …

This in vitro study examined the effect of eluate from heat-activated, chemically activated,
and microwave-activated denture base resins on cell viability of primary cultures of human …

OBJECTIVE Hypoglycemia may exert proarrhythmogenic effects on the heart via
sympathoadrenal stimulation and hypokalemia. Hypoglycemia-induced cardiac …

Hypoglycemia is associated with increased cardiovascular mortality in trials of intensive
therapy in type 2 diabetes mellitus (T2DM). We previously observed an increase in …

Platelet activation and aggregation are mediated by thrombin cleavage of the exodomain of
the PAR1 receptor. The specificity of thrombin for PAR1 is enhanced by binding to a hirudin …

Patients afflicted with congenitally missing teeth are a unique patient population for
consideration of treatment with osseointegrated implants. Frequently, these patients have …

Gene therapy potentially allows local delivery and expression of cytokines, growth factors,
and other mediators. In spite of increasing knowledge of the human genome, applications in …

Introduction The American Heart Association (AHA)/American College of Cardiology (ACC)
guidelines for the classification of heart failure (HF) are descriptive but lack precise and …