Monocyte subset accumulation in the human heart following acute myocardial infarction and the role of the spleen as monocyte reservoir

AM van der Laan, EN Ter Horst, R Delewi… - European heart …, 2014 - academic.oup.com
Aims Monocytes are critical mediators of healing following acute myocardial infarction (AMI),
making them an interesting target to improve myocardial repair. The purpose of this study …

[HTML][HTML] Modulators of macrophage polarization influence healing of the infarcted myocardium

EN Ter Horst, N Hakimzadeh, AM Van der Laan… - International journal of …, 2015 - mdpi.com
To diminish heart failure development after acute myocardial infarction (AMI), several
preclinical studies have focused on influencing the inflammatory processes in the healing …

Type II secretory phospholipase A2 in cardiovascular disease: a mediator in atherosclerosis and ischemic damage to cardiomyocytes?

HWM Niessen, PAJ Krijnen, CA Visser… - Cardiovascular …, 2003 - academic.oup.com
Inflammatory reactions contribute to the pathogenesis of cardiovascular conditions such as
atherosclerosis and ischemic damage in acute myocardial infarction (AMI). Among the …

[HTML][HTML] Infectious myocarditis: the role of the cardiac vasculature

L Woudstra, LJM Juffermans, AC van Rossum… - Heart Failure …, 2018 - Springer
Infectious myocarditis is the result of an immune response to a microbial infection of the
heart. The blood vessels of the heart, both the intramyocardial microvasculature and the …

[HTML][HTML] Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses

M Rieckmann, M Delgobo, C Gaal… - The Journal of …, 2019 - Am Soc Clin Investig
T cell autoreactivity is a hallmark of autoimmune diseases but can also benefit self-
maintenance and foster tissue repair. Here, we investigated whether heart-specific T cells …

Acute inflammation is persistent locally in burn wounds: a pivotal role for complement and C-reactive protein

F van de Goot, PAJ Krijnen… - Journal of burn care …, 2009 - academic.oup.com
Severe burns can cause major complications, such as infection and deforming scar
formation. Burn wounds induce an excessive inflammatory response. Serum levels of …

[HTML][HTML] Homocysteine-induced apoptosis in endothelial cells coincides with nuclear NOX2 and peri-nuclear NOX4 activity

JA Sipkens, N Hahn, CS van den Brand… - Cell biochemistry and …, 2013 - Springer
Apoptosis of endothelial cells related to homocysteine (Hcy) has been reported in several
studies. In this study, we evaluated whether reactive oxygen species (ROS)-producing …

[HTML][HTML] NOX5 expression is increased in intramyocardial blood vessels and cardiomyocytes after acute myocardial infarction in humans

NE Hahn, C Meischl, T Kawahara, RJP Musters… - The American journal of …, 2012 - Elsevier
Reactive oxygen species producing NADPH oxidases play important roles under different
(patho) physiological conditions. NOX1, NOX2, and NOX4 are important sources of reactive …

[HTML][HTML] Elevated monocyte-specific type I interferon signalling correlates positively with cardiac healing in myocardial infarct patients but interferon alpha application …

EN Ter Horst, PAJ Krijnen, N Hakimzadeh… - Basic Research in …, 2019 - Springer
Monocytes are involved in adverse left ventricular (LV) remodelling following myocardial
infarction (MI). To provide therapeutic opportunities we aimed to identify gene transcripts in …

The role of complement in the acute phase response after burns

HI Korkmaz, PAJ Krijnen, MMW Ulrich, E De Jong… - Burns, 2017 - Elsevier
Severe burns induce a complex systemic inflammatory response characterized by a typical
prolonged acute phase response (APR) that starts approximately 4–8 h after-burn and …