[HTML][HTML] Study designs and statistical analyses for biomarker research

M Gosho, K Nagashima, Y Sato - Sensors, 2012 - mdpi.com
Biomarkers are becoming increasingly important for streamlining drug discovery and
development. In addition, biomarkers are widely expected to be used as a tool for disease …

Vitamin E has a beneficial effect on nonalcoholic fatty liver disease: a meta-analysis of randomized controlled trials

K Sato, M Gosho, T Yamamoto, Y Kobayashi, N Ishii… - Nutrition, 2015 - Elsevier
Objectives Vitamin E is often used in the treatment of nonalcoholic fatty liver disease
(NAFLD), including nonalcoholic steatohepatitis (NASH); however, the magnitude of …

Alogliptin, a dipeptidyl peptidase 4 inhibitor, prevents the progression of carotid atherosclerosis in patients with type 2 diabetes: the study of preventive effects of …

T Mita, N Katakami, H Yoshii, T Onuma… - Diabetes …, 2016 - Am Diabetes Assoc
OBJECTIVE Recent experimental studies have shown that dipeptidyl peptidase 4 (DPP-4)
inhibitors have antiatherosclerotic benefits in glucagon-like peptide 1–dependent and …

Sitagliptin attenuates the progression of carotid intima-media thickening in insulin-treated patients with type 2 diabetes: the sitagliptin preventive study of intima-media …

T Mita, N Katakami, T Shiraiwa, H Yoshii… - Diabetes …, 2016 - Am Diabetes Assoc
OBJECTIVE The effect of additional treatment with oral hypoglycemic agents on the
progression of atherosclerosis remains unknown in insulin-treated patients with type 2 …

Prevalence of Helicobacter pylori Infection by Birth Year and Geographic Area in Japan

J Ueda, M Gosho, Y Inui, T Matsuda… - …, 2014 - Wiley Online Library
Background Helicobacter pylori (H. pylori)‐related diseases are responsible for a
tremendous amount of morbidity and mortality in Japan. We estimated the prevalence of H …

A comparison of bias‐adjusted generalized estimating equations for sparse binary data in small‐sample longitudinal studies

M Gosho, R Ishii, H Noma, K Maruo - Statistics in Medicine, 2023 - Wiley Online Library
Using a generalized estimating equation (GEE) can lead to a bias in regression coefficients
for a small sample or sparse data. The bias‐corrected GEE (BCGEE) and penalized GEE …

Propensity score analysis of regorafenib versus trifluridine/tipiracil in patients with metastatic colorectal cancer refractory to standard chemotherapy (REGOTAS): a …

T Moriwaki, S Fukuoka, H Taniguchi… - The …, 2018 - academic.oup.com
Background This study compared the efficacy of regorafenib and trifluridine/tipiracil (TFTD)
in patients with metastatic colorectal cancer (mCRC) who are refractory to standard …

Bias in odds ratios from logistic regression methods with sparse data sets

M Gosho, T Ohigashi, K Nagashima, Y Ito… - Journal of …, 2023 - jstage.jst.go.jp
Background: Logistic regression models are widely used to evaluate the association
between a binary outcome and a set of covariates. However, when there are few study …

Fluctuations in routine blood count might signal severe immune-related adverse events in melanoma patients treated with nivolumab

Y Fujisawa, K Yoshino, A Otsuka, T Funakoshi… - Journal of …, 2017 - Elsevier
Background Although nivolumab significantly prolongs survival of metastatic melanoma,
about 10% of patients experience severe, even fatal immune-related adverse events (irAEs) …

Robot-assisted training as self-training for upper-limb hemiplegia in chronic stroke: a randomized controlled trial

T Takebayashi, K Takahashi, S Amano, M Gosho… - Stroke, 2022 - Am Heart Assoc
Background: This study aimed to examine whether robotic self-training improved upper-
extremity function versus conventional self-training in mild-to-moderate hemiplegic chronic …