Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis …

M Hedman, J Hartikainen, M Syvänne, J Stjernvall… - Circulation, 2003 - Am Heart Assoc
Background—Catheter-based intracoronary vascular endothelial growth factor (VEGF) gene
transfer is a potential treatment for coronary heart disease. However, only limited data are …

[HTML][HTML] Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled …

K Mäkinen, H Manninen, M Hedman, P Matsi… - Molecular Therapy, 2002 - cell.com
Vascular endothelial growth factor (VEGF) gene therapy may be useful for the treatment of
lower-limb ischemia. The objectives of this study were to evaluate safety and angiographic …

DNA hypomethylation and methyltransferase expression in atherosclerotic lesions

MO Hiltunen, MP Turunen, TP Häkkinen… - Vascular …, 2002 - journals.sagepub.com
Arterial smooth muscle cell (SMC) migration and proliferation are central features in
atherogenesis. Altered gene expression and cell proliferation in atherosclerotic lesions have …

Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine …

J Rutanen, TT Rissanen, JE Markkanen, M Gruchala… - Circulation, 2004 - Am Heart Assoc
Background—It is unclear what is the most efficient vector and growth factor for induction of
therapeutic vascular growth in the heart. Furthermore, the histological nature of …

Large vessel cell heterogeneity and plasticity: focus in aortic aneurysms

S Jauhiainen, M Kiema, M Hedman… - … , and Vascular Biology, 2022 - Am Heart Assoc
Smooth muscle cells and endothelial cells have a remarkable level of plasticity in vascular
pathologies. In thoracic and abdominal aortic aneurysms, smooth muscle cells have been …

Adenoviral intramyocardial VEGF-DΔNΔC gene transfer increases myocardial perfusion reserve in refractory angina patients: a phase I/IIa study with 1-year follow-up

J Hartikainen, I Hassinen, A Hedman… - European heart …, 2017 - academic.oup.com
Aims We evaluated for the first time the effects of angiogenic and lymphangiogenic AdVEGF-
DΔNΔC gene therapy in patients with refractory angina. Methods and results Thirty patients …

[HTML][HTML] Synthetic mRNA encoding VEGF-A in patients undergoing coronary artery bypass grafting: design of a phase 2a clinical trial

V Anttila, A Saraste, J Knuuti, P Jaakkola… - … Therapy-Methods & …, 2020 - cell.com
Therapeutic angiogenesis may improve outcomes in patients with coronary artery disease
undergoing surgical revascularization. Angiogenic factors may promote blood vessel growth …

[HTML][HTML] Left atrial appendage morphology in patients with suspected cardiogenic stroke without known atrial fibrillation

M Korhonen, A Muuronen, O Arponen, P Mustonen… - PLoS …, 2015 - journals.plos.org
The left atrial appendage (LAA) is the typical origin for intracardiac thrombus formation.
Whether LAA morphology is associated with increased stroke/TIA risk is controversial and, if …

[HTML][HTML] Artificial intelligence for hospital health care: Application cases and answers to challenges in European hospitals

M Klumpp, M Hintze, M Immonen, F Ródenas-Rigla… - Healthcare, 2021 - mdpi.com
The development and implementation of artificial intelligence (AI) applications in health care
contexts is a concurrent research and management question. Especially for hospitals, the …

[HTML][HTML] Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting

V Anttila, A Saraste, J Knuuti, M Hedman, P Jaakkola… - Molecular Therapy, 2023 - cell.com
Vascular endothelial growth factor A (VEGF-A) has therapeutic cardiovascular effects, but
delivery challenges have impeded clinical development. We report the first clinical study of …