Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial
Summary Background Cardiosphere-derived cells (CDCs) reduce scarring after myocardial
infarction, increase viable myocardium, and boost cardiac function in preclinical models. We …
infarction, increase viable myocardium, and boost cardiac function in preclinical models. We …
Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial …
Objectives: This study sought to report full 1-year results, detailed magnetic resonance
imaging analysis, and determinants of efficacy in the prospective, randomized, controlled …
imaging analysis, and determinants of efficacy in the prospective, randomized, controlled …
Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial …
R Gallet, J Dawkins, J Valle, E Simsolo… - European heart …, 2017 - academic.oup.com
Aims Naturally secreted nanovesicles known as exosomes are required for the regenerative
effects of cardiosphere-derived cells (CDCs), and exosomes mimic the benefits of CDCs in …
effects of cardiosphere-derived cells (CDCs), and exosomes mimic the benefits of CDCs in …
Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells
Objectives: The goal of this study was to conduct a direct head-to-head comparison of
different stem cell types in vitro for various assays of potency and in vivo for functional …
different stem cell types in vitro for various assays of potency and in vivo for functional …
Safety and efficacy of allogeneic cell therapy in infarcted rats transplanted with mismatched cardiosphere-derived cells
K Malliaras, TS Li, D Luthringer, J Terrovitis, K Cheng… - Circulation, 2012 - Am Heart Assoc
Background—Cardiosphere-derived cells (CDCs) are an attractive cell type for tissue
regeneration, and autologous CDCs are being tested clinically. However, autologous …
regeneration, and autologous CDCs are being tested clinically. However, autologous …
Y RNA fragment in extracellular vesicles confers cardioprotection via modulation of IL‐10 expression and secretion
Cardiosphere‐derived cells (CDC s) reduce myocardial infarct size via secreted
extracellular vesicles (CDC‐EVs), including exosomes, which alter macrophage …
extracellular vesicles (CDC‐EVs), including exosomes, which alter macrophage …
Cardiospheres and cardiosphere-derived cells as therapeutic agents following myocardial infarction
M Kreke, RR Smith, L Marbán… - Expert review of …, 2012 - Taylor & Francis
Heart disease is a major cause of morbidity and mortality. Cellular therapies hold significant
promise for patients with heart disease. Heart-derived progenitor cells are capable of …
promise for patients with heart disease. Heart-derived progenitor cells are capable of …
Enhancing retention and efficacy of cardiosphere-derived cells administered after myocardial infarction using a hyaluronan-gelatin hydrogel
RR Smith, E Marbán, L Marbán - Biomatter, 2013 - Taylor & Francis
Cardiosphere-derived cells (CDCs) are under clinical development and are currently being
tested in a clinical trial enrolling patients who have undergone a myocardial infarction …
tested in a clinical trial enrolling patients who have undergone a myocardial infarction …
Intracoronary ALLogeneic heart STem cells to Achieve myocardial Regeneration (ALLSTAR): a randomized, placebo-controlled, double-blinded trial
RR Makkar, DJ Kereiakes, F Aguirre… - European heart …, 2020 - academic.oup.com
Abstract Aims Cardiosphere-derived cells (CDCs) are cardiac progenitor cells that exhibit
disease-modifying bioactivity in various models of cardiomyopathy and in previous clinical …
disease-modifying bioactivity in various models of cardiomyopathy and in previous clinical …
[HTML][HTML] Repeated intravenous cardiosphere-derived cell therapy in late-stage Duchenne muscular dystrophy (HOPE-2): a multicentre, randomised, double-blind …
Summary Background Cardiosphere-derived cells (CDCs) ameliorate skeletal and cardiac
muscle deterioration in experimental models of Duchenne muscular dystrophy. The HOPE-2 …
muscle deterioration in experimental models of Duchenne muscular dystrophy. The HOPE-2 …