User profiles for "author:Leonard Hofstra"

Leonard Hofstra

Cardioloog
Verified email at cardiologiecentra.nl
Cited by 12416

Past, present, and future of annexin A5: from protein discovery to clinical applications

HH Boersma, BLJH Kietselaer, LML Stolk… - Journal of nuclear …, 2005 - Soc Nuclear Med
In this article, we review the clinical aspects of imaging with the programmed cell–detecting
protein annexin A5 (anxA5). AnxA5 binds to phosphatidylserine, which is one of the “eat me” …

Elevated levels of circulating DNA and chromatin are independently associated with severe coronary atherosclerosis and a prothrombotic state

JI Borissoff, IA Joosen, MO Versteylen… - … , and vascular biology, 2013 - Am Heart Assoc
Objective—Aberrant neutrophil activation occurs during the advanced stages of
atherosclerosis. Once primed, neutrophils can undergo apoptosis or release neutrophil …

Noninvasive detection of plaque instability with use of radiolabeled annexin A5 in patients with carotid-artery atherosclerosis

BLJH Kietselaer, CPM Reutelingsperger… - … England Journal of …, 2004 - Mass Medical Soc
To the Editor: Although progressive stenosis of the arterial lumen constitutes the basis for
ischemic symptoms in atherosclerotic vascular disease, acute vascular events are for the …

Additive value of semiautomated quantification of coronary artery disease using cardiac computed tomographic angiography to predict future acute coronary …

MO Versteylen, BL Kietselaer, PC Dagnelie… - Journal of the American …, 2013 - jacc.org
Objectives: The purpose of this study was to investigate whether the use of a semiautomated
plaque quantification algorithm (reporting volumetric and geometric plaque properties) …

[HTML][HTML] Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype

LJ Schurgers, IA Joosen, EM Laufer, MLL Chatrou… - 2012 - journals.plos.org
Background Vitamin K-antagonists (VKA) are treatment of choice and standard care for
patients with venous thrombosis and thromboembolic risk. In experimental animal models as …

Patients using vitamin K antagonists show increased levels of coronary calcification: an observational study in low-risk atrial fibrillation patients

B Weijs, Y Blaauw, RJMW Rennenberg… - European heart …, 2011 - academic.oup.com
Abstract Aims Vitamin K antagonists (VKA) are currently the most frequently used drug to
prevent ischaemic stroke in atrial fibrillation (AF) patients. However, VKA use has been …

The extent of coronary atherosclerosis is associated with increasing circulating levels of high sensitive cardiac troponin T

EM Laufer, AMA Mingels, MHM Winkens… - … , and vascular biology, 2010 - Am Heart Assoc
Objective—This study explored the relationship between coronary atherosclerotic plaque
burden and quantifiable circulating levels of troponin measured with a recently introduced …

Molecular imaging of interstitial alterations in remodeling myocardium after myocardial infarction

SWM van den Borne, S Isobe, JW Verjans… - Journal of the American …, 2008 - jacc.org
Objectives: The purpose of this study was to evaluate interstitial alterations in myocardial
remodeling using a radiolabeled Cy5. 5-RGD imaging peptide (CRIP) that targets …

Counting heads in the war against cancer: defining the role of annexin A5 imaging in cancer treatment and surveillance

MF Corsten, L Hofstra, J Narula… - Cancer Research, 2006 - AACR
The unveiling of the heterogeneous nature of cell death modes has compromised the long-
lived consensus that cancer treatment typically kills cancer cells through apoptosis …

Targeted imaging for cell death in cardiovascular disorders

A Shekhar, P Heeger, C Reutelingsperger… - JACC: Cardiovascular …, 2018 - jacc.org
Cell death is desirable in cancer cells and undesirable in organs with limited regenerative
potential, like the heart. Cell death comes in many forms, but only apoptosis and to a lesser …