Studies from both in vivo and in vitro model systems have provided an initial skeleton of the
potential signaling pathways that might regulate cardiac genes during growth and …

preventive measures for virus-mediated heart disease could be instituted. Phase 1 is
defined as the period of time when active replication of live virus is occurring within the …

During the last decade, a variety of morphological, physiological, and biochemical studies
have provided an improved definition of the alterations in myocardial structure and function …

To study the mechanisms that activate expression of the atrial natriuretic factor (ANF) gene
during pressure-induced hypertrophy, we have developed and characterized an in vivo …

Enteroviruses such as Coxsackievirus B3 can cause dilated cardiomyopathy, but the
mechanism of this pathology is unknown. Mutations in cytoskeletal proteins such as …

Nonalcoholic fatty liver (NAFL) and its sequelae are growing health problems. We performed
a genome-wide association study of NAFL, cirrhosis and hepatocellular carcinoma, and …

Background We aimed to assess the efficacy and safety of two neutralising monoclonal
antibody therapies (sotrovimab [Vir Biotechnology and GlaxoSmithKline] and BRII-196 plus …

We report a genome-wide association study of venous thromboembolism (VTE)
incorporating 81,190 cases and 1,419,671 controls sampled from six cohorts. We identify 93 …

Coxsackievirus B3 (CVB3) infections induce myocarditis in humans and mice. Little is known
about the molecular characteristics of CVB3 that activate the cellular immunity responsible …

Nebulin is a giant modular sarcomeric protein that has been proposed to play critical roles in
myofibrillogenesis, thin filament length regulation, and muscle contraction. To investigate the …