Background Elevated plasma levels of atrial natriuretic peptide (ANP) and the N-terminal
fragment of the ANP prohormone (N-ANP) are associated with decreased left ventricular …

DNA methylation is a covalent biochemical modification controlling chromatin structure and
gene expression. Exercise elicits gene expression changes that trigger structural and …

Background—B-type natriuretic peptide (BNP) is a predictor of short-and medium-term
prognosis across the spectrum of acute coronary syndromes (ACS). The N-terminal fragment …

Epigenetic modification through DNA methylation is implicated in metabolic disease. Using
whole-genome promoter methylation analysis of skeletal muscle from normal glucose …

To evaluate the short-and long-term effects of beta-adrenergic blockade (metoprolol) as well
as the reaction to withdrawal and readministration of metoprolol in severe heart failure, 33 …

Study objective To investigate whether a dose-effect relationship exists between the severity
of obstructive sleep apnea (OSA) and subclinical indicators of myocardial or vascular …

To evaluate cardiac structure and function as well as blood pressure in the obstructive sleep
apnoea syndrome (OSAS), we investigated 61 male patients and 61 male controls with M …

The permanent modification of soluble and protein-associated tyrosine by nitration results in
the formation of 3-nitrotyrosine, which can be used as a marker of “nitro-oxidative” damage …

Background Fibroblast growth factor (FGF) 21, a novel member of the FGF family, plays a
role in a variety of endocrine functions, including regulation of glucose and lipid metabolism …

Interleukin (IL)-6 is a proinflammatory cytokine shown to modify insulin sensitivity. Elevated
plasma levels of IL-6 are observed in insulin-resistant states. Interestingly, plasma IL-6 …