Physical activity and sleep duration are established risk factors for many diseases, but their
aetiology is poorly understood, partly due to relying on self-reported evidence. Here we …

Aims Most patients who receive implantable cardioverter defibrillators (ICDs) for primary
prevention do not receive therapy during the lifespan of the ICD, whilst up to 50% of sudden …

Systemic inflammation markers have been linked to increased cancer risk and mortality in a
number of studies. However, few studies have estimated pre-diagnostic associations of …

Background Blood pressure lowering is an established strategy for preventing microvascular
and macrovascular complications of diabetes, but its role in the prevention of diabetes itself …

Background Higher levels of physical activity (PA) are associated with a lower risk of
cardiovascular disease (CVD). However, uncertainty exists on whether the inverse …

Esophageal squamous cell carcinoma (ESCC) shows remarkable variation in incidence that
is not fully explained by known lifestyle and environmental risk factors. It has been …

Background Physical inactivity is associated with an increased risk of major chronic
diseases, although uncertainty exists about which chronic diseases, themselves, might …

Cancer risk is determined by a complex interplay of environmental and heritable factors.
Polygenic risk scores (PRS) provide a personalized genetic susceptibility profile that may be …

Biomarkers for early detection of breast cancer may complement population screening
approaches to enable earlier and more precise treatment. The blood proteome is an …

Circulating insulin-like growth factor I (IGF-I) is positively associated with the risks of
colorectal, breast, and prostate cancer, but evidence for other less common cancers is …