Candidate gene and genome-wide association studies (GWAS) have identified genetic
variants that modulate risk for human disease; many of these associations require further …

The development of new knowledge around the genetic determinants of variable drug action
has naturally raised the question of how this new knowledge can be used to improve the …

Importance Polygenic risk scores comprising millions of single-nucleotide polymorphisms
(SNPs) could be useful for population-wide coronary heart disease (CHD) screening …

Untargeted metabolomics is an analytical approach with numerous applications serving as
an effective metabolic phenotyping platform to characterize small molecules within a …

FOXA1, estrogen receptor α (ERα) and GATA3 independently predict favorable outcome in
breast cancer patients, and their expression correlates with a differentiated, luminal tumor …

Background—ECG QRS duration, a measure of cardiac intraventricular conduction, varies≈
2-fold in individuals without cardiac disease. Slow conduction may promote re-entrant …

Chronic obstructive pulmonary disease (COPD) is a common, complex disease associated
with substantial morbidity and mortality. COPD is defined by irreversible airflow obstruction; …

Genetic association studies often examine features independently, potentially missing
subpopulations with multiple phenotypes that share a single cause. We describe an …

Background—New drugs are routinely screened for I Kr blocking properties thought to
predict QT prolonging and arrhythmogenic liability. However, recent data suggest that …

Importance Coronary artery calcium score and polygenic risk score have each separately
been proposed as novel markers to identify risk of coronary heart disease (CHD), but no …