User profiles for "author:Jesús Medina"

Jesús Medina

Catedrático de la Universidad de Cádiz // Full Professor
Verified email at uca.es
Cited by 4172

Approach to the pathogenesis and treatment of nonalcoholic steatohepatitis

J Medina, LI Fernández-Salazar, L García-Buey… - Diabetes …, 2004 - Am Diabetes Assoc
Nonalcoholic steatohepatitis (NASH) represents an advanced stage of fatty liver disease
developed in the absence of alcohol abuse. Its increasing prevalence in western countries …

Therapeutic inertia in the treatment of hyperglycaemia in patients with type 2 diabetes: a systematic review

K Khunti, MB Gomes, S Pocock… - Diabetes, Obesity …, 2018 - Wiley Online Library
Aims Therapeutic inertia, defined as the failure to initiate or intensify therapy in a timely
manner according to evidence‐based clinical guidelines, is a key reason for uncontrolled …

[PDF][PDF] Angiogenesis in chronic inflammatory liver disease

J Medina, AG Arroyo, F Sánchez‐Madrid… - …, 2004 - Wiley Online Library
Intrahepatic hypoxia may occur during the inflammatory and fibrotic processes that
characterize several chronic liver diseases of viral and autoimmune origin. As a …

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective …

JM Axten, JR Medina, Y Feng, A Shu… - Journal of medicinal …, 2012 - ACS Publications
Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is activated in response
to a variety of endoplasmic reticulum stresses implicated in numerous disease states …

Formal concept analysis via multi-adjoint concept lattices

J Medina, M Ojeda-Aciego, J Ruiz-Calvino - Fuzzy sets and systems, 2009 - Elsevier
Several fuzzifications of formal concept analysis have been proposed to deal with uncertain
information. In this paper, we focus on concept lattices under a multi-adjoint paradigm, which …

Similarity-based unification: a multi-adjoint approach

J Medina, M Ojeda-Aciego, P Vojtáš - Fuzzy sets and systems, 2004 - Elsevier
The aim of this paper is to build a formal model for similarity-based fuzzy unification in multi-
adjoint logic programs. Specifically, a general framework of logic programming which allows …

Discovery of GSK2656157: an optimized PERK inhibitor selected for preclinical development

JM Axten, SP Romeril, A Shu, J Ralph… - ACS medicinal …, 2013 - ACS Publications
We recently reported the discovery of GSK2606414 (1), a selective first in class inhibitor of
protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), which inhibited PERK …

The Raman laser spectrometer for the ExoMars rover mission to Mars

F Rull, S Maurice, I Hutchinson, A Moral, C Perez… - Astrobiology, 2017 - liebertpub.com
Abstract The Raman Laser Spectrometer (RLS) on board the ESA/Roscosmos ExoMars
2020 mission will provide precise identification of the mineral phases and the possibility to …

Multi-adjoint logic programming with continous semantics

J Medina, M Ojeda-Aciego, P Vojtáš - International Conference on Logic …, 2001 - Springer
Considering different implication operators, such as Lukasiewicz, Gödel or product
implication in the same logic program, naturally leads to the allowance of several adjoint …

Multi-adjoint t-concept lattices

J Medina, M Ojeda-Aciego - Information Sciences, 2010 - Elsevier
The t-concept lattice is introduced as a set of triples associated to graded tabular information
interpreted in a non-commutative fuzzy logic. Following the general techniques of formal …