Active metal template synthesis of rotaxanes, catenanes and molecular shuttles
Active metal template synthesis is a powerful new strategy for the construction of rotaxanes,
catenanes and other mechanically interlocked molecular structures. The key feature is that …
catenanes and other mechanically interlocked molecular structures. The key feature is that …
“Click-triazole” coordination chemistry: Exploiting 1, 4-disubstituted-1, 2, 3-triazoles as ligands
JD Crowley, DA McMorran - Click Triazoles, 2012 - Springer
Access to readily functionalized ligand architectures is of crucial importance in a range of
different areas including catalysis, metallopharmaceuticals, bioimaging …
different areas including catalysis, metallopharmaceuticals, bioimaging …
Plešovice zircon—a new natural reference material for U–Pb and Hf isotopic microanalysis
Matrix-matched calibration by natural zircon standards and analysis of natural materials as a
reference are the principle methods for achieving accurate results in microbeam U–Pb …
reference are the principle methods for achieving accurate results in microbeam U–Pb …
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
S Ripke, C O'dushlaine, K Chambert, JL Moran… - Nature …, 2013 - nature.com
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …
[PDF][PDF] Modeling linkage disequilibrium increases accuracy of polygenic risk scores
Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …
become more accurate as training sample sizes increase. The standard approach for …
Biochemical and physiological effects of sterol alterations in yeast—a review
LW Parks, SJ Smith, JH Crowley - Lipids, 1995 - Springer
Considerable progress has been made in the selection and characterization of mutants that
are defective in the synthesis of ergosterol in the yeast, Saccharomyces cerevisiae …
are defective in the synthesis of ergosterol in the yeast, Saccharomyces cerevisiae …
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk …
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk …
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
Characterized primarily by a low body-mass index, anorexia nervosa is a complex and
serious illness, affecting 0.9–4% of women and 0.3% of men,–, with twin-based heritability …
serious illness, affecting 0.9–4% of women and 0.3% of men,–, with twin-based heritability …
[PDF][PDF] Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases
Regulatory and coding variants are known to be enriched with associations identified by
genome-wide association studies (GWASs) of complex disease, but their contributions to …
genome-wide association studies (GWASs) of complex disease, but their contributions to …
Calibrating the end-Permian mass extinction
The end-Permian mass extinction was the most severe biodiversity crisis in Earth history. To
better constrain the timing, and ultimately the causes of this event, we collected a suite of …
better constrain the timing, and ultimately the causes of this event, we collected a suite of …