[HTML][HTML] A comparison of two LDL cholesterol targets after ischemic stroke

P Amarenco, JS Kim, J Labreuche… - … England Journal of …, 2020 - Mass Medical Soc
Background The use of intensive lipid-lowering therapy by means of statin medications is
recommended after transient ischemic attack (TIA) and ischemic stroke of atherosclerotic …

Benefit of targeting a LDL (low-density lipoprotein) cholesterol< 70 mg/dL during 5 years after ischemic stroke

P Amarenco, JS Kim, J Labreuche, H Charles… - Stroke, 2020 - Am Heart Assoc
Background and Purpose—The TST trial (Treat Stroke to Target) evaluated the benefit of
targeting a LDL (low-density lipoprotein) cholesterol of< 70 mg/dL to reduce the risk of …

Risk of subsequent disabling or fatal stroke in patients with transient ischaemic attack or minor ischaemic stroke: an international, prospective cohort study

C Hobeanu, PC Lavallée, H Charles… - The Lancet …, 2022 - thelancet.com
Background Patients who have had a transient ischaemic attack or minor stroke have an
increased risk of cardiovascular events for the following 5 years. We aimed to assess 5-year …

Effect of atherosclerosis on 5-year risk of major vascular events in patients with transient ischaemic attack or minor ischaemic stroke: an international prospective …

PC Lavallée, H Charles, GW Albers, LR Caplan… - The Lancet …, 2023 - thelancet.com
Background The prevalence of atherosclerosis and the long-term risk of major vascular
events in people who have had a transient ischaemic attack or minor ischaemic stroke …

Yield of dual therapy with statin and ezetimibe in the treat stroke to target trial

P Amarenco, JS Kim, J Labreuche, H Charles… - Stroke, 2022 - Am Heart Assoc
Background: In atherosclerotic stroke, lipid-lowering treatment with a target LDL (low-density
lipoprotein) cholesterol of< 70 compared with 100±10 mg/dL reduced the risk of subsequent …

Carotid atherosclerosis evolution when targeting a low-density lipoprotein cholesterol concentration< 70 mg/dL after an ischemic stroke of atherosclerotic origin

P Amarenco, C Hobeanu, J Labreuche, H Charles… - Circulation, 2020 - Am Heart Assoc
Background: The TST trial (Treat Stroke to Target) showed the benefit of targeting a low-
density lipoprotein cholesterol (LDL-C) concentration of< 70 mg/dL in terms of reducing the …

[HTML][HTML] Regulating metabolic inflammation by nutritional modulation

H Charles-Messance, KAJ Mitchelson… - Journal of Allergy and …, 2020 - Elsevier
Metabolic inflammation (metaflammation) is characteristic of obesity-related metabolic
disorders, associated with increased risk of development of type 2 diabetes, nonalcoholic …

[HTML][HTML] Intracranial hemorrhage in the TST trial

P Amarenco, JS Kim, J Labreuche, H Charles… - Stroke, 2022 - journals.lww.com
Background and Purpose: Although statins are effective in secondary prevention of ischemic
stroke, they are also associated with an increase risk of intracranial hemorrhage (ICH) in …

Five-year prognosis after TIA or minor ischemic stroke in Asian and non-Asian populations

T Hoshino, S Uchiyama, LKS Wong, K Kitagawa… - Neurology, 2021 - AAN Enterprises
Objective To determine long-term vascular outcomes of Asian patients who experienced TIA
or minor ischemic stroke and to compare the outcomes of Asian patients with those of non …

[PDF][PDF] Complement factor H inhibits CD47-mediated resolution of inflammation

B Calippe, S Augustin, F Beguier, H Charles-Messance… - Immunity, 2017 - cell.com
Variants of the CFH gene, encoding complement factor H (CFH), show strong association
with age-related macular degeneration (AMD), a major cause of blindness. Here, we used …