From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I

M Naghavi, P Libby, E Falk, SW Casscells, S Litovsky… - Circulation, 2003 - Am Heart Assoc
Atherosclerotic cardiovascular disease results in> 19 million deaths annually, and coronary
heart disease accounts for the majority of this toll. Despite major advances in treatment of …

[PDF][PDF] Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the …

J Boren, MJ Chapman, RM Krauss… - European heart …, 2020 - academic.oup.com
OP-EHEA191011_online 2313..2340 Page 1 Low-density lipoproteins cause atherosclerotic
cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus …

Extracellular vesicles for drug delivery

P Vader, EA Mol, G Pasterkamp… - Advanced drug delivery …, 2016 - Elsevier
Extracellular vesicles (EVs) are cell-derived membrane vesicles, and represent an
endogenous mechanism for intercellular communication. Since the discovery that EVs are …

[HTML][HTML] Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

RC Lai, F Arslan, MM Lee, NSK Sze, A Choo, TS Chen… - Stem cell …, 2010 - Elsevier
Human ESC-derived mesenchymal stem cell (MSC)-conditioned medium (CM) was
previously shown to mediate cardioprotection during myocardial ischemia/reperfusion injury …

[HTML][HTML] Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and …

F Arslan, RC Lai, MB Smeets, L Akeroyd, A Choo… - Stem cell …, 2013 - Elsevier
We have previously identified exosomes as the paracrine factor secreted by mesenchymal
stem cells. Recently, we found that the key features of reperfusion injury, namely loss of …

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

A Okbay, BML Baselmans, JE De Neve, P Turley… - Nature …, 2016 - nature.com
Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a …

[HTML][HTML] Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium

L Timmers, SK Lim, F Arslan, JS Armstrong, IE Hoefer… - Stem cell …, 2008 - Elsevier
Although paracrine effects of mesenchymal stem cells (MSCs) have been suggested
previously, cardioprotection by human MSC secretions has never been demonstrated …

Arterial remodeling: mechanisms and clinical implications

MR Ward, G Pasterkamp, AC Yeung, C Borst - Circulation, 2000 - Am Heart Assoc
In normal arteries, remodeling is a homeostatic response to changes in the flow and
circumferential stretch to restore normal shear stress and wall tension, respectively. 12 …

Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury

L Timmers, JPS Henriques, DPV de Kleijn… - Journal of the American …, 2009 - jacc.org
Objectives: This study sought to examine whether exenatide is capable of reducing
myocardial infarct size. Background: Exenatide is a glucagon-like peptide (GLP)-1 analogue …

Composition of carotid atherosclerotic plaque is associated with cardiovascular outcome: a prognostic study

WE Hellings, W Peeters, FL Moll, SRD Piers… - Circulation, 2010 - Am Heart Assoc
Background—Identification of patients at risk for primary and secondary manifestations of
atherosclerotic disease progression is based mainly on established risk factors. The …