From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I
Atherosclerotic cardiovascular disease results in> 19 million deaths annually, and coronary
heart disease accounts for the majority of this toll. Despite major advances in treatment of …
heart disease accounts for the majority of this toll. Despite major advances in treatment of …
[PDF][PDF] Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the …
OP-EHEA191011_online 2313..2340 Page 1 Low-density lipoproteins cause atherosclerotic
cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus …
cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus …
Extracellular vesicles for drug delivery
P Vader, EA Mol, G Pasterkamp… - Advanced drug delivery …, 2016 - Elsevier
Extracellular vesicles (EVs) are cell-derived membrane vesicles, and represent an
endogenous mechanism for intercellular communication. Since the discovery that EVs are …
endogenous mechanism for intercellular communication. Since the discovery that EVs are …
[HTML][HTML] Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
Human ESC-derived mesenchymal stem cell (MSC)-conditioned medium (CM) was
previously shown to mediate cardioprotection during myocardial ischemia/reperfusion injury …
previously shown to mediate cardioprotection during myocardial ischemia/reperfusion injury …
[HTML][HTML] Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and …
We have previously identified exosomes as the paracrine factor secreted by mesenchymal
stem cells. Recently, we found that the key features of reperfusion injury, namely loss of …
stem cells. Recently, we found that the key features of reperfusion injury, namely loss of …
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a …
because of limitations on sample size in previous studies. Subjective well-being, a …
[HTML][HTML] Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium
L Timmers, SK Lim, F Arslan, JS Armstrong, IE Hoefer… - Stem cell …, 2008 - Elsevier
Although paracrine effects of mesenchymal stem cells (MSCs) have been suggested
previously, cardioprotection by human MSC secretions has never been demonstrated …
previously, cardioprotection by human MSC secretions has never been demonstrated …
Arterial remodeling: mechanisms and clinical implications
MR Ward, G Pasterkamp, AC Yeung, C Borst - Circulation, 2000 - Am Heart Assoc
In normal arteries, remodeling is a homeostatic response to changes in the flow and
circumferential stretch to restore normal shear stress and wall tension, respectively. 12 …
circumferential stretch to restore normal shear stress and wall tension, respectively. 12 …
Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury
L Timmers, JPS Henriques, DPV de Kleijn… - Journal of the American …, 2009 - jacc.org
Objectives: This study sought to examine whether exenatide is capable of reducing
myocardial infarct size. Background: Exenatide is a glucagon-like peptide (GLP)-1 analogue …
myocardial infarct size. Background: Exenatide is a glucagon-like peptide (GLP)-1 analogue …
Composition of carotid atherosclerotic plaque is associated with cardiovascular outcome: a prognostic study
WE Hellings, W Peeters, FL Moll, SRD Piers… - Circulation, 2010 - Am Heart Assoc
Background—Identification of patients at risk for primary and secondary manifestations of
atherosclerotic disease progression is based mainly on established risk factors. The …
atherosclerotic disease progression is based mainly on established risk factors. The …