Background: Pulmonary hypertension (PH) is a common and morbid complication of left
heart disease with 2 subtypes: isolated post-capillary pulmonary hypertension (Ipc-PH) and …

Importance Pulmonary hypertension (PH) is diagnosed by a mean pulmonary arterial
pressure (mPAP) value of at least 25 mm Hg during right heart catheterization (RHC). While …

Background: Circulating B-type natriuretic peptide (BNP) concentrations strongly predict
mortality in patients with heart failure (HF). Both cardiac and extracardiac stimuli influence …

Background: Calcific aortic stenosis (CAS) is the most common valvular heart disease in
older adults and has no effective preventive therapies. Genome-wide association studies …

Background Inflammation may contribute to incident heart failure (HF). Rheumatoid arthritis
(RA), a prototypic inflammatory condition, may serve as a model for understanding …

Aims Mitral valve prolapse (MVP) is a common valvular heart disease with a prevalence of>
2% in the general adult population. Despite this high incidence, there is a limited …

Importance Current guidelines recommend evaluation for echocardiographically estimated
right ventricular systolic pressure (RVSP) greater than 40 mm Hg; however, this threshold …

Background Transthoracic echocardiography (TTE) is used to estimate pulmonary artery
systolic pressure, but an adequate tricuspid regurgitation velocity (TRV) needed to calculate …

Genome-wide association studies (GWASs) primarily performed in European-ancestry (EA)
populations have identified numerous loci associated with body mass index (BMI). However …

Increased oestrogen is a strong epidemiological risk factor for development of pulmonary
arterial hypertension (PAH) in patients, associated with metabolic defects. In addition …