The human mitochondrial genome is extremely small compared with the nuclear genome,
and mitochondrial genetics presents unique clinical and experimental challenges. Despite …

As the second most common age related neurodegenerative disease after Alzheimer's
disease, the health, social and economic impact resulting from Parkinson's disease will …

Mitochondria are double‐membrane‐bound organelles that are present in all nucleated
eukaryotic cells and are responsible for the production of cellular energy in the form of ATP …

Mitochondrial DNA (mtDNA) deletions are a primary cause of mitochondrial disease and are
likely to have a central role in the aging of postmitotic tissues. Understanding the mechanism …

Mitochondrial diseases are clinically heterogeneous disorders caused by a wide spectrum
of mutations in genes encoded by either the nuclear or the mitochondrial genome …

Objective Cerebral atrophy is a correlate of clinical progression in multiple sclerosis (MS).
Mitochondria are now established to play a part in the pathogenesis of MS. Uniquely …

Mitochondrial DNA (mtDNA) defects are a relatively common cause of inherited disease and
have been implicated in both ageing and cancer. MtDNA encodes essential subunits of the …

Mitochondrial diseases are among the most common and most complex of all inherited
genetic diseases. The involvement of both the mitochondrial and nuclear genome presents …

The mammalian mitochondrial genome (mtDNA) is a small double-stranded DNA molecule
that is exclusively transmitted down the maternal line. Pathogenic mtDNA mutations are …

Mitochondrial diseases are some of the most common inherited neurometabolic disorders,
and major progress has been made in our understanding, diagnosis, and treatment of these …