The perception of the Z-disc in striated muscle has undergone significant changes in the
past decade. Traditionally, the Z-disc has been viewed as a passive constituent of the …

During the last 15 years, the perception of the cardiac z-disc has undergone substantial
changes. Initially viewed as a structural component at the lateral boundaries of the …

Background: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is
increasingly used to treat cardiogenic shock. However, VA-ECMO might hamper myocardial …

Objectives Patients undergoing surgery for severe aortic stenosis (SAS) can be treated with
either transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement …

Signaling by the calcium-dependent phosphatase calcineurin profoundly influences the
growth and gene expression of cardiac and skeletal muscle. Calcineurin binds to calsarcins …

Summary Background Post-COVID syndrome (PCS) is an important sequela of COVID-19,
characterised by symptom persistence for> 3 months, post-acute symptom development …

Biomechanical stress ie, attributable to pressure overload, leads to cardiac hypertrophy and
may ultimately cause heart failure. Yet, it is still unclear how mechanical stress is sensed …

Objectives This study sought to determine if percutaneous coronary intervention (PCI) prior
to transcatheter aortic valve replacement (TAVR) in patients with significant coronary artery …

Background—Osteopontin, a glycoprotein that can be detected in plasma, was found to be
upregulated in several animal models of cardiac failure and may thus represent a new …

Cardiac hypertrophy is an independent risk for heart failure (HF) and sudden death.
Deciphering signalling pathways dependent on extracellular calcium (Ca2+) influx that …