User profiles for "author:David Winlaw"

David Winlaw

Cincinnati Children's Hospital Medical Center
Verified email at cchmc.org
Cited by 8939

[HTML][HTML] The health digital twin to tackle cardiovascular disease—a review of an emerging interdisciplinary field

G Coorey, GA Figtree, DF Fletcher, VJ Snelson… - NPJ digital …, 2022 - nature.com
Potential benefits of precision medicine in cardiovascular disease (CVD) include more
accurate phenotyping of individual patients with the same condition or presentation, using …

Congenital heart disease: current knowledge about causes and inheritance

GM Blue, EP Kirk, GF Sholler, RP Harvey… - The Medical Journal of …, 2012 - mja.com.au
Congenital heart disease: current knowledge about causes and inheritance | The Medical
Journal of Australia MJA Basic Search Advanced search search Use the Advanced search …

European heart rhythm association (EHRA)/heart rhythm society (HRS)/Asia pacific heart rhythm society (APHRS)/latin American heart rhythm society (LAHRS) expert …

AAM Wilde, C Semsarian, MF Márquez, AS Shamloo… - Europace, 2022 - academic.oup.com
Purpose Genetic testing has advanced significantly since the publication of the 2011
HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the …

Redefining expectations of long-term survival after the Fontan procedure: twenty-five years of follow-up from the entire population of Australia and New Zealand

Y d'Udekem, AJ Iyengar, JC Galati, V Forsdick… - Circulation, 2014 - Am Heart Assoc
Background—The life expectancy of patients undergoing a Fontan procedure is unknown.
Methods and Results—Follow-up of all 1006 survivors of the 1089 patients who underwent a …

[PDF][PDF] Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and …

EP Kirk, M Sunde, MW Costa, SA Rankin… - The American Journal of …, 2007 - cell.com
The T-box family transcription factor gene TBX20 acts in a conserved regulatory network,
guiding heart formation and patterning in diverse species. Mouse Tbx20 is expressed in …

[PDF][PDF] Contribution of global rare copy-number variants to the risk of sporadic congenital heart disease

R Soemedi, IJ Wilson, J Bentham, R Darlay… - The American Journal of …, 2012 - cell.com
Previous studies have shown that copy-number variants (CNVs) contribute to the risk of
complex developmental phenotypes. However, the contribution of global CNV burden to the …

[HTML][HTML] NAD deficiency, congenital malformations, and niacin supplementation

H Shi, A Enriquez, M Rapadas… - … England Journal of …, 2017 - Mass Medical Soc
Background Congenital malformations can be manifested as combinations of phenotypes
that co-occur more often than expected by chance. In many such cases, it has proved difficult …

Increased nitric oxide production in heart failure

DS Winlaw, AM Keogh, CG Schyvens, PM Spratt… - The Lancet, 1994 - Elsevier
The role of nitric oxide in heart failure is unknown. The high-capacity inducible isoform of
nitric oxide synthase is present in the myocardium of patients with idiopathic dilated …

A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells

JR Stehn, NK Haass, T Bonello, M Desouza, G Kottyan… - Cancer research, 2013 - AACR
The actin cytoskeleton is a potentially vulnerable property of cancer cells, yet
chemotherapeutic targeting attempts have been hampered by unacceptable toxicity. In this …

The Fontan epidemic: population projections from the Australia and New Zealand Fontan registry

C Schilling, K Dalziel, R Nunn, K Du Plessis… - International journal of …, 2016 - Elsevier
Background The number and age demographic of the future Fontan population is unknown.
Methods Population projections were calculated probabilistically using microsimulation …