Whereas multiple national, international, and trial registries for heart failure have been
created, international standards for clinical assessment and outcome measurement do not …

Background—Elevated renin-angiotensin-aldosterone system activity correlates with left
ventricular hypertrophy (LVH) and cardiovascular risk, but the relative contributions of …

Peroxisome proliferator activated receptor-gamma (PPARγ) is a nuclear receptor that
regulates adipocyte differentiation, and possibly lipid metabolism and insulin sensitivity. As …

Mitochondrial dysfunction is an important factor in the pathogenesis of age-related diseases,
including neurodegenerative diseases like Alzheimer's and Parkinson's spectrum disorders …

Alzheimer's disease is a quintessential 'unmet medical need', accounting for∼ 65% of
progressive cognitive impairment among the elderly, and 700,000 deaths in the United …

Genetic factors influence the development of type II diabetes mellitus, but genetic loci for the
most common forms of diabetes have not been identified. A genomic scan was conducted to …

The three-dimensional structure of the ligand-binding region of human E-selectin has been
determined at 2.0 Å resolution. The structure reveals limited contact between the two …

Summary The Initial rolling Interaction of leukocytes with the blood vessel wall during
leukocyte trafficking has been postulated to rely on members of the selectin family of …

Bipolar disorder (BP) is a disabling and often life-threatening disorder that affects≈ 1% of
the population worldwide. To identify genetic variants that increase the risk of BP, we …

Technological and scientific advances, stemming in large part from the Human Genome and
HapMap projects, have made large-scale, genome-wide investigations feasible and cost …