Global birth prevalence of congenital heart defects 1970–2017: updated systematic review and meta-analysis of 260 studies

Y Liu, S Chen, L Zühlke, GC Black… - International journal …, 2019 - academic.oup.com
Background Globally, access to healthcare and diagnostic technologies are known to
substantially impact the reported birth prevalence of congenital heart disease (CHD) …

Association of apolipoprotein E genotypes with lipid levels and coronary risk

AM Bennet, E Di Angelantonio, Z Ye, F Wensley… - Jama, 2007 - jamanetwork.com
ContextPrevious reviews of associations of apolipoprotein E (apoE) genotype and coronary
disease have been dominated by smaller studies that are liable to biases. ObjectiveTo …

Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66 155 cases and 91 307 controls

Z Ye, EHC Liu, JPT Higgins, BD Keavney, GDO Lowe… - The Lancet, 2006 - thelancet.com
Background Variants of certain haemostatic genes (such as that encoding factor V Leiden)
are involved in the development of venous thrombosis, but studies of such variants in …

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

E Evangelou, HR Warren, D Mosen-Ansorena… - Nature …, 2018 - nature.com
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular
disease. We report the largest genetic association study of blood pressure traits (systolic …

Association analyses based on false discovery rate implicate new loci for coronary artery disease

CP Nelson, A Goel, AS Butterworth, S Kanoni… - Nature …, 2017 - nature.com
Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified
66 loci at'genome-wide significance'(P< 5× 10− 8) at the time of this analysis, but a much …

Genomic risk prediction of coronary artery disease in 480,000 adults: implications for primary prevention

M Inouye, G Abraham, CP Nelson, AM Wood… - Journal of the American …, 2018 - jacc.org
Background: Coronary artery disease (CAD) has substantial heritability and a polygenic
architecture. However, the potential of genomic risk scores to help predict CAD outcomes …

Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk

A Thompson, E Di Angelantonio, N Sarwar, S Erqou… - Jama, 2008 - jamanetwork.com
Context The importance of the cholesteryl ester transfer protein (CETP) pathway in coronary
disease is uncertain. Study of CETP genotypes can help better understand the relevance of …

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

HR Warren, E Evangelou, CP Cabrera, H Gao, M Ren… - Nature …, 2017 - nature.com
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse …

Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing

A Sifrim, MP Hitz, A Wilsdon, J Breckpot, SHA Turki… - Nature …, 2016 - nature.com
Congenital heart defects (CHDs) have a neonatal incidence of 0.8–1%(refs.,). Despite
abundant examples of monogenic CHD in humans and mice, CHD has a low absolute …

Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency

RE Dickinson, H Griffin, V Bigley… - Blood, The Journal …, 2011 - ashpublications.org
The human syndrome of dendritic cell, monocyte, B and natural killer lymphoid deficiency
presents as a sporadic or autosomal dominant trait causing susceptibility to mycobacterial …