Because of its dynamic nature, the composition and structure of the myocardial collagen
network can be reversibly modified to adapt to transient cardiac injuries. In response to …

Diffuse myocardial fibrosis resulting from the excessive deposition of collagen fibres through
the entire myocardium is encountered in a number of chronic cardiac diseases. This lesion …

Myocardial fibrosis impairs cardiac function, in addition to facilitating arrhythmias and
ischemia, and thus influences the evolution and outcome of cardiac diseases. Its …

Background—This study was designed to investigate whether myocardial collagen content
is related to myocardial stiffness in patients with essential hypertension. Methods and …

Background Myocardial fibrosis is a hallmark of hypertrophic cardiomyopathy and a
proposed substrate for arrhythmias and heart failure. In animal models, profibrotic genetic …

Background—We investigated whether increased collagen type I synthesis and deposition
contribute to enhancement of myocardial fibrosis and deterioration of cardiac function in …

Objectives: This individually randomized, open-label, parallel-group pilot study was
designed to test the hypothesis that the ability of loop diuretics to interfere with cardiac …

Objectives: We attempted to correlate echocardiographic analysis of diastolic function with
changes of myocardial collagen in middle-aged patients with heart failure (HF) despite …

Background We investigated whether serum concentration of carboxy-terminal propeptide of
procollagen type I (PIP), a marker of collagen type I synthesis, can be used to assess the …

Background—Obesity and diabetes mellitus are important metabolic risk factors and
frequent comorbidities in heart failure with preserved ejection fraction. They contribute to …