Abstract
In long-term, 1-year follow-up, uptitration of angiotensin-converting enzyme inhibitor and nitrate therapy over established doses can further improve severe functional mitral regurgitation in patients with dilated cardiomyopathy due to a reversal of heart failure-related left ventricular remodeling. With marked left ventricular enlargement, >6.8 cm end-diastolic diameter, heart failure remodeling may be irreversible and resistant to further medical intervention.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
MeSH terms
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Aged
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Angiotensin-Converting Enzyme Inhibitors / administration & dosage*
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Female
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Heart Failure / drug therapy*
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Hemodynamics / drug effects
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Humans
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Isosorbide Dinitrate / administration & dosage*
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Lisinopril / administration & dosage*
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Male
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Middle Aged
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Mitral Valve Insufficiency / diagnostic imaging
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Mitral Valve Insufficiency / drug therapy*
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Severity of Illness Index
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Ultrasonography
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Vasodilator Agents / administration & dosage*
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Ventricular Remodeling / drug effects
Substances
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Angiotensin-Converting Enzyme Inhibitors
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Vasodilator Agents
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Lisinopril
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Isosorbide Dinitrate