Objective: To summarize the association of simple renal cyst (SRC) with abdominal aortic aneurysm (AAA), we reviewed currently available clinical studies with a systematic literature search and meta-analytic evaluation.
Methods: To identify all case-control studies evaluating the association of SRC with AAA, databases including MEDLINE and Embase were searched through April 2015 using web-based search engines (PubMed and Ovid). For each study, data regarding SRC prevalence in both the AAA and control groups were used to generate unadjusted odds ratios (ORs) and 95% confidence intervals. When an adjusted OR (by the use of multivariable logistic regression) was available, we preferentially abstracted the adjusted OR rather than an unadjusted OR.
Results: Of 139 potentially relevant articles screened initially, 5 eligible case-control studies enrolling a total of 2897 participants were identified and included. A pooled analysis of seven estimates from the five studies demonstrated a statistically significant 2.54-fold prevalence of SRC in patients with AAA relative to subjects without AAA (OR, 2.54; 95% confidence interval, 1.93-3.34; P < .00001).
Conclusions: Our meta-analytic evaluation demonstrated 2.5-fold prevalence of SRC in patients with AAA relative to subjects without AAA, which suggests that SRC is associated with AAA.
Copyright © 2016 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.