Pathophysiological Mechanisms of Tobacco-Related CVD

Salman Salahuddin; Dorairaj Prabhakaran; Ambuj Roy

doi:10.1016/j.gheart.2012.05.003

Pathophysiological Mechanisms of Tobacco-Related CVD

Glob Heart. 2012 Jul;7(2):113-20. doi: 10.1016/j.gheart.2012.05.003.

Authors

Salman Salahuddin¹, Dorairaj Prabhakaran², Ambuj Roy¹

Affiliations

¹ Department of Cardiology, Cardiothoracic Sciences Centre, All India Institute of Medical Sciences, New Delhi, India.
² Centre for Chronic Disease Control and Director, Center of Excellence in Cardio-metabolic Risk Reduction in South Asia, Public Health Foundation of India, New Delhi, India.

PMID: 25691307
DOI: 10.1016/j.gheart.2012.05.003

Abstract

Cigarette smoking is a leading preventable risk factor for the development and progression of cardiovascular diseases (CVDs). Epidemiologic studies conclusively prove that both active smoking and secondhand smoke contribute significantly to morbidity and mortality related to CVD. Cigarette smoke is a mixture of several toxic chemicals, of which nicotine, carbon monoxide, and oxidant chemicals are most commonly implicated in the pathogenesis of cardiovascular disease. Tobacco causes endothelial dysfunction, inflammation, insulin resistance, alteration of lipid profile, hemodynamic alterations, and a hypercoagulable state. All of these act synergistically as pathobiologic mechanisms of atherothrombosis in tobacco users.