Interleukin-23 serum levels in patients affected by peripheral arterial disease

Antonio David; Salvatore Saitta; Giovanni De Caridi; Filippo Benedetto; Mafalda Massara; Domenica Claudia Risitano; Francesco Saverio Venuti; Francesco Spinelli; Sebastiano Gangemi

doi:10.1016/j.clinbiochem.2011.12.010

Interleukin-23 serum levels in patients affected by peripheral arterial disease

Clin Biochem. 2012 Feb;45(3):275-8. doi: 10.1016/j.clinbiochem.2011.12.010. Epub 2011 Dec 20.

Authors

Antonio David¹, Salvatore Saitta, Giovanni De Caridi, Filippo Benedetto, Mafalda Massara, Domenica Claudia Risitano, Francesco Saverio Venuti, Francesco Spinelli, Sebastiano Gangemi

Affiliation

¹ Department of Neurosciences, Psichiatric and Anesthesiological Sciences, University of Messina, Italy.

PMID: 22209993
DOI: 10.1016/j.clinbiochem.2011.12.010

Abstract

Objectives: To clarify whether interleukin (IL)-23 is involved in peripheral arterial disease (PAD).

Design and methods: We evaluated IL-23 serum levels, in 29 patients suffering from lower extremity PAD and in 30 healthy subjects.

Results: IL-23 serum levels were higher during the three times (T0, T1 and T2) compared to the control group, although only statistically significant for T0 and T2: T0 (15.83 ± 22.08 vs. 8.08 ± 8.62 pg ml, p=0.026), T1 (16.10 ± 23.71 vs. 8.08 ± 8.62 pg/ml, p=0.101), T2 (15.06 ± 16.72 vs. 8.08 ± 8.62 pg/ml, p=0.005).

Conclusion: For the first time, our data gives us reason to believe there is an involvement of IL-23 in PAD.

MeSH terms

Adult
Aged
Aged, 80 and over
Case-Control Studies
Female
Humans
Interleukin-23 Subunit p19 / blood*
Male
Middle Aged
Peripheral Arterial Disease / blood*

Substances

IL23A protein, human
Interleukin-23 Subunit p19