Glycated haemoglobin: what is the diagnostic yield at shortened testing intervals?

Diabetes Res Clin Pract. 2011 Nov;94(2):e40-2. doi: 10.1016/j.diabres.2011.07.034. Epub 2011 Aug 15.

Abstract

The proportion of sequential HbA1c exceeding critical difference (diagnostic yield), where it is considered clinically significant change, was calculated for different testing intervals. 12% and 26% of repeat HbA1c exceeded the critical difference before 30 and 90 days testing intervals, respectively. Repeating HbA1c within 4 weeks has poor diagnostic yield and should be avoided.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers / blood
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / diagnosis*
  • Female
  • Glycated Hemoglobin / metabolism*
  • Humans
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Reproducibility of Results
  • Singapore
  • Time Factors
  • Young Adult

Substances

  • Biomarkers
  • Glycated Hemoglobin A
  • hemoglobin A1c protein, human