Local IRBs, multicenter trials, and the ethics of internal amendments

MeSH terms

• Clinical Protocols*
• Consent Forms / standards
• Ethics Committees, Research* / organization & administration
• Humans
• Multicenter Studies as Topic*
• Patient Selection
• Placebos
• Randomized Controlled Trials as Topic / ethics*
• Research Design*
• Research Subjects
• Schizophrenia / drug therapy
• Selection Bias