Abstract
This review summarizes recent developments in our understanding of the molecular basis of platelet activation by two distinct types of surface receptor, the immunoglobulin GPVI, and the integrin alphaIIb beta3 (also known as GPIIbIIIa). These two classes of receptor signal through similar yet distinct tyrosine kinase-based signaling cascades leading to activation of phospholipase C gamma2. The significance of these signaling cascades in platelet adhesion and platelet aggregation at arterial rates of shear is discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Collagen / metabolism
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Enzyme Activation
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Enzyme Precursors / metabolism
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Humans
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Intracellular Signaling Peptides and Proteins
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Models, Biological
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Molecular Sequence Data
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Platelet Activation
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Platelet Adhesiveness
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Platelet Aggregation
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Platelet Glycoprotein GPIIb-IIIa Complex / metabolism
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Platelet Glycoprotein GPIIb-IIIa Complex / physiology*
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Platelet Membrane Glycoproteins / metabolism
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Platelet Membrane Glycoproteins / physiology*
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Protein-Tyrosine Kinases / metabolism
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Signal Transduction*
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Syk Kinase
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src-Family Kinases / metabolism
Substances
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Enzyme Precursors
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Intracellular Signaling Peptides and Proteins
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Platelet Glycoprotein GPIIb-IIIa Complex
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Platelet Membrane Glycoproteins
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platelet membrane glycoprotein VI
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Collagen
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Protein-Tyrosine Kinases
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SYK protein, human
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Syk Kinase
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src-Family Kinases