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Critical Reviews™ in Immunology

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ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Role of Complement in Innate Immunity and Infections

Volume 30, Issue 1, 2010, pp. 47-52
DOI: 10.1615/CritRevImmunol.v30.i1.30
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ABSTRACT

The complement system is a major player in our innate defense and constitutes one of the key effector mechanisms of antibody-dependent and -independent immunity. The complement system is composed of a large number of proteins found in the circulation, in other body fluids, and in tissues in a biologically inactive state. Biological activity of the complement system is generated following activation of the complement system via three initiating pathways, which ultimately lead to the activation of C3, the central component of complement, and the generation of a large number of biological functions such as anaphylaxis, chemotaxis, and phagocytosis. The crucial role of C3 activation is evidenced by the susceptibility of individuals with C3 deficiency to infections with various types of microorganisms and the inability to properly handle immune complexes, self-debris, etc. This review will focus on the protective role of the lectin pathway of complement and the alternative pathway in bacterial defense.

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