* Corresponding authors

^a NMR Metabonomics Laboratory, Laboratory of Chemistry, Department of Biosciences, University of Kuopio, Kuopio, Finland

^b Computational Medicine Research Group, Institute of Clinical Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, P.O. Box 5000, FI-90014 University of Oulu, Oulu, Finland
E-mail: mika.ala-korpela@computationalmedicine.fi
Web: http://www.computationalmedicine.fi/
Tel: + 358 50 35 35 457

^c Department of Clinical Physiology and the Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Central Hospital, Turku, Finland

^d National Institute of Health and Wellbeing, Department of Child and Adolescent Health, Oulu, Finland

^e Department of Epidemiology and Public Health, Imperial College London, London, UK

^f Institute of Health Sciences and Biocenter Oulu, University of Oulu, Oulu, Finland

^g Department of Clinical Physiology, Tampere University Hospital and University of Tampere, Tampere, Finland

^h Department of Clinical Chemistry, Tampere University Hospital and University of Tampere, Tampere, Finland

ⁱ Department of Medicine, University of Turku and Turku University Central Hospital, Turku, Finland

^j Department of Internal Medicine and Biocenter Oulu, Clinical Research Center, University of Oulu, Oulu, Finland