IL-6 signalling in patients with acute ST-elevation myocardial infarction

https://doi.org/10.1016/j.rinim.2013.11.002Get rights and content
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Highlights

  • Circulating levels of IL-6 and CRP, but not sgp130 and sIL-6R were associated with the extent of myocardial necrosis.

  • Circulating levels of sgp130 were weakly associated with impaired LV function and glucometabolic state.

  • Circulating levels of sIL-6R were not associated with either impaired LV function or glucometabolic state.

Abstract

Cytokines of the IL-6 family have been related to infarct size and prognosis in patients with myocardial infarction. The aims of the present study were to elucidate possible associations between myocardial necrosis and left ventricular impairment and members of the IL-6 transsignalling system including soluble (s) IL-6R and (s) glycoprotein 130 (sgp130) in patients with ST-elevation myocardial infarction (STEMI) treated with primary PCI.

In blood samples from 1028 STEMI patients, collected in-hosptial, we found significant correlations between peak TnT and IL-6 and CRP (p < 0.001, all) and between IL-6 and CRP and LV ejection fraction and NT-proBNP (p < 0.001, all). On the contrary, no significant associations were found between peak TnT and sgp130 or sIL-6R. Furthermore sgp130 was significantly elevated in diabetic patients and also associated with the glucometabolic state.

In conclusion, circulating levels of IL-6 and CRP, but not the soluble forms of the receptor (sIL-6R) or the receptor signalling subunit (sgp130) were associated with the extent of myocardial necrosis. The biological importance of the IL-6/gp130-mediated signalling pathways in patients with acute myocardial infarction and dysglycemia should be further elucidated.

Keywords

ST-elevation myocardial infarction
IL-6
sgp130
sIL-6R
Myocardial necrosis

Abbreviations

ALD
alcoholic liver disease
sgp130
soluble glycoprotein 130
sIL-6R
soluble interleukin -6 receptor
PCI
percutaneous coronary intervention
STEMI
ST-elevation myocardial infarction
LVEF
left ventricular ejection fraction

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