Mini-Focus: Aortic Valve DiseaseLipoprotein(a) Induces Human Aortic Valve Interstitial Cell Calcification
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Visual Abstract
Key Words
oxidized phospholipids
Raman spectroscopy
real-time PCR
stenosis
Abbreviations and Acronyms
ALP
alkaline phosphatase
apo(a)
apolipoprotein(a)
BMP
bone morphogenetic protein
FWHM
full width half maximum
HAVIC
human aortic valve interstitial cell
LDL
low-density lipoprotein
Lp(a)
lipoprotein(a)
LOX-1
oxidized LDL receptor 1
MAPK
mitogen-activated protein kinase
MGP
matrix Gla protein
mRNA
messenger ribonucleic acid
OxPL
oxidized phospholipid
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This work was supported by the Canadian Institutes of Health Research and the Heart and Stroke Foundation of Quebec, Canada. Dr. Thanassoulis is a consultant for and has received a research grant from Ionis; and is on the advisory board for Amgen. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
All authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the JACC: Basic to Translational Science author instructions page.
© 2017 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.