Original-experimentalEditorial commentaryPredicting sudden cardiac death in healthy humans: Is there more to autonomic balance than we know?
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Association between resting heart rate and coronary artery disease, stroke, sudden death and noncardiovascular diseases: A meta-analysis
2016, CMAJCitation Excerpt :High resting heart rate could increase hemodynamic stress and shorten the diastolic phase, which could then increase mechanical load, tensile stress, low and oscillatory shear stress, blood pressure and cardiac work, thereby increasing oxygen consumption; these direct detrimental effects could cause coronary atherosclerosis and myocardial ischemia.2,9,54 High resting heart rate is a marker of sympathetic overactivity, which is associated with an increased risk of sudden death that usually results from ventricular fibrillation.55 Ischemic episodes are more likely to trigger serious arrhythmias in the context of high heart rate, and the beneficial effect of β-blockade on ventricular fibrillation may be mediated primarily by heart rate reduction.9
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