Original articleImpact of Preload and Afterload on Global and Regional Right Ventricular Function and Pressure: A Quantitative Echocardiography Study
Section snippets
Methods
This study included 17 young healthy individuals with no history of cardiovascular or metabolic diseases, including hypertension or diabetes. Baseline electrocardiograms were normal and all participants were in sinus rhythm. The institutional review board approved the protocol and all participants signed informed consent before enrollment in the study.
Two-dimensional, Doppler, and Doppler tissue echocardiographic evaluations were performed at baseline, after hypoxic induced pulmonary
Results
The 17 participants included were 31 ± 9 years of age and 13 (76%) were male. They had mean body mass index of 24 ± 3 kg/m2 and a blood pressure of 115 ± 13/79 ± 9 mm Hg. They were in average physical condition, with maximal oxygen consumption per unit time of 36 ± 6 mL/kg equaling 98 ± 7% of the expected value for age and sex. On echocardiography LV ejection fraction was 61 ± 4%. The baseline echocardiographic measures of RV size and estimates of function and diastolic and systolic pressures
Discussion
This study is the first to examine the impact of changes in loading conditions on newer quantitative echocardiographic methods on RV function in human beings. The study confirms previous findings of load independence of IVA as a measure of RV contractility. The findings also suggest that PA acceleration time may be a helpful adjunct in the determination of the hemodynamic mechanism of increased pulmonary pressure.
The models used for the manipulation of the loading conditions of the RV were
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Cited by (0)
Supported by National Institutes of Health grant HL71478; American Heart Association grants 56051Z and 0525727Z; US Public Health Service grant M01-RR00585; and Danish Heart Foundation research fellowship grant 04-10-B109-A166-22192 (Dr Kjaergaard).