Biochimica et Biophysica Acta (BBA) - Biomembranes
Volume 1818, Issue 8, August 2012, Pages 2020-2029
Functional consequences of abnormal Cx43 expression in the heart☆
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Highlights
► Review on the remodeling of cardiac ventricular gap junctions and its consequences. ► Heart remodeling results in heterogeneity and dephosphorylation of Cx43 expression. ► Consequences of abnormal Cx43 expression for the development of arrhythmias. ► Therapies aimed to improve the Cx43 expression levels, reduced arrhythmogenesis.
Abbreviations
BZ
border zone
CV
conduction velocity
Cx43
connexin43
DCM
dilated cardiomyopathy
ERP
effective refractory period
HCM
hypertrophic cardiomyopathy
ICM
ischemic cardiomyopathy
IDs
intercalated disks
LV
left ventricle
Keywords
Connexin43
Heterogeneity
Arrhythmia
Conduction velocity
Fibrosis
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This article is part of a Special Issue entitled: The Communicating junctions, composition, structure and characteristics.
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