Valvular Heart DiseaseValue of the “TAVI2-SCORe” Versus Surgical Risk Scores for Prediction of One Year Mortality in 511 Patients Who Underwent Transcatheter Aortic Valve Implantation
Section snippets
Methods
Patients with symptomatic severe aortic stenosis (valve area <1.0 cm2; and/or <0.6 cm2/m2; and/or mean gradient ≥40 mm Hg) who underwent TAVI at the Leiden University Medical Center (Leiden, The Netherlands) and Centro Cardiologico Monzino IRCCS (Milan, Italy) between November 2007 and November 2012 were included. All patients were considered to be at high or prohibitive surgical risk, according to the Heart Team decision.
Baseline patient demographic data, cardiovascular risk factors, symptoms,
Results
A total of 511 patients (median age 82 [77 to 86] years, 38% men) were included, of which 207 (41%) were treated in Leiden and 304 (59%) in Milan. A total of 36 patients were excluded because of incomplete data to calculate respective conventional surgical risk scores. Baseline characteristics are listed in Table 1. All patients were at high or prohibitive surgical risk as indicated by mean LES-I, LES-II, and STS score. No patients were lost to follow-up for evaluation of the study end point.
Discussion
This study indicates that TAVI2-SCORe is a simple and novel risk model for accurate prediction of 1-year mortality after TAVI, based on preprocedural baseline patient characteristics. Moreover, the TAVI2-SCORe outperforms discriminatory and calibration abilities of conventional surgical risk scores, including LES-I, LES-II, and STS score.
Cumulative 30-day and 1-year mortality observed in our registry is in line with the respective mortality of 7.4% to 9.7% and 24% reported in the 2 largest
Disclosures
Dr. Debonnaire is supported by a Sadra Medical Research Grant (Boston Scientific, Natick, MA) and holds a European Association of Cardiovascular Imaging Research Grant. Dr. Kamperidis received a European Society of Cardiology Clinical Training Grant. Dr. Katsanos is supported by the Hellenic Society of Cardiology (Athens, Greece). Dr. Joyce holds a European Society Of Cardiology Clinical Training Grant. Dr. Delgado received consulting fees from St. Jude Medical. No specific funding was provided
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