Arrhythmias and conduction disturbancesRelation of Elevated Serum Uric Acid Levels to Incidence of Atrial Fibrillation in Patients With Type 2 Diabetes Mellitus
Section snippets
Methods
We followed for 10 years a sample of 400 Caucasian patients with type 2 diabetes, who were clinically free from AF at baseline. As detailed in Figure 1, these participants were selected by a simple random sampling technique from the whole cohort (n = 1,718) of type 2 diabetic outpatients, who regularly attended the diabetes clinic at the “Sacro Cuore” Hospital of Negrar (Verona) during 2000 to 2001 after excluding patients who did not meet the inclusion criteria for the study.
The sample size of
Results
The 400 randomly selected participants did not significantly differ from the initially eligible sample of 1,718 outpatients with type 2 diabetes in terms of age (64 ± 10 vs 66 ± 4 years), male gender (59% vs 60%), diabetes duration (6 ± 7 vs 8 ± 4 years), HbA1c (7.6 ± 1.6% vs 7.4 ± 1.0%), hypertension (70% vs 74%), obesity (44% vs 47%), and previous CHD (9% vs 11%) and congestive HF (2% vs 3.5%).
Mean (±SD) SUA level was 308 ± 83 μmol/L (median: 300 μmol/L, range: 120 to 580 μmol/L) for all
Discussion
Elevated SUA is an emerging risk factor for cardiovascular morbidity and mortality1, 2 and may contribute to the development and progression of CKD.16
Recent epidemiologic studies suggest that elevated SUA is also significantly associated with an increased prevalence of AF in nondiabetic subjects.5, 6, 7, 8 More interestingly, the investigators of the Atherosclerosis Risk in Communities study, a multiethnic cohort of 15,382 AF-free United States adults, have reported that elevated SUA was
Disclosures
The authors have no conflicts of interest to disclose.
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2018, Canadian Journal of CardiologyCitation Excerpt :In diabetic patients, nonalcoholic fatty liver disease has been associated with increased AF prevalence, independently of several AF risk factors.43 Hyperuricemia is encountered in up to one-third of diabetic patients,44 whereas in patients with DM and no history of AF, elevated uric acid levels were associated with an increased incidence of AF after adjustment for multiple confounders.45 Data linking dyslipidemia and AF are controversial, although some studies reported an increased AF risk in patients with low high-density lipoprotein levels.20
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