Coronary artery diseaseFrequency of Takotsubo Cardiomyopathy in Postmenopausal Women Presenting With an Acute Coronary Syndrome
Section snippets
Methods
The study cohort consisted of all middle-aged and older women (≥45 years of age) presumed to be peri- or postmenopausal with positive troponin-I cardiac biomarker (Siemens Centaur Assay, Siemens, Tarrytown, New York; Sensitivity >0.006 ng/ml, positive >0.04 ng/ml) who required inpatient treatment for any medical condition at a regional community hospital with Level 1 Trauma certification (Fresno, California) from July 21, 2011 to July 20, 2012. The decision to admit the patient was made by the
Results
There were 1,297 patients with positive troponin-I biomarkers (Siemens Centaur Assay; positive >0.04 ng/ml). Most of these patients (75.1%; n = 974) did not meet criteria for ACS whereas the remaining 24.9% (n = 323) fulfilled an ACS diagnosis (see Figure 2).
Overall, there were 22 patients who fulfilled the criteria for TC (see Table 1). The average age of all patients with TC was 64.7 ± 11.5 years. The peak troponin was 5.9 ± 10.8 ng/ml and average ejection fraction during the episode was 34 ±
Discussion
This study demonstrates an incidence of 5.9% for TC over a 1-year period in PMW admitted with a suspected ACS. Using these prespecified, expanded criteria for TC, the incidence in these women is greater than that reported in a recent study in all patients with ACS5 and in an international registry.10 As this study focused only on middle-aged and older women and used a broader definition than that used in other studies, the approximate threefold greater incidence from the present investigation
Disclosures
The authors have no conflicts of interest to disclose.
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