Coronary artery diseaseUsefulness of Serial Assessment of B-Type Natriuretic Peptide, Troponin I, and C-Reactive Protein to Predict Left Ventricular Remodeling After Acute Myocardial Infarction (from the REVE-2 Study)
Section snippets
Methods
REVE-2 was a multicenter study that enrolled 246 patients with anterior wall Q-wave MI from 8 centers in France (Appendix) from February 2006 to September 2008. Inclusion criteria were hospitalization within 24 hours after symptom onset and ≥3 LV segments of the infarct zone that were akinetic at predischarge echocardiography. Exclusion criteria were inadequate echographic image quality, life-limiting noncardiac disease, significant valvular disease, or previous Q-wave MI. The research protocol
Results
Characteristics of the 246 patients who formed the study population are listed in Table 1.
Baseline echocardiographic study was performed at a mean of 4.0 ± 1.5 days after the MI. During the 1-year follow-up period, 3 patients died (all from cardiovascular causes) and 1 patient underwent heart transplantation. In addition, 3 patients had recurrent MIs during the follow-up period. Echocardiographic follow-up was achieved in 226 of the 242 eligible patients (93%, 1 patient was lost to follow-up
Discussion
The present study provides new information on biological markers associated with LV dilation after MI. We selected 3 biomarkers that assess different pathways implicated in LV remodeling. BNP is synthesized in the ventricular myocardium and released into the circulation in response to ventricular dilation and pressure overload.3 These characteristics make BNP a first-line LV remodeling biomarker candidate. Several investigations, therefore, were performed on the association between BNP and LV
Acknowledgment
The investigators thank Stéphane Dequand and Michel Deneve for monitoring the study and for their help in the Lille Core Echocardiographic Laboratory.
References (24)
- et al.
B-type natriuretic peptide in cardiovascular disease
Lancet
(2003) - et al.
Prognostic value of C-reactive protein and cardiac troponin I in primary percutaneous interventions for ST-elevation myocardial infarction
Am Heart J
(2006) - et al.
Early inflammation and risk of long-term development of heart failure and mortality in survivors of acute myocardial infarction predictive role of C-reactive protein
J Am Coll Cardiol
(2006) - et al.
Left ventricular remodeling after anterior wall acute myocardial infarction in modern clinical practice (from the REmodelage VEntriculaire [REVE] study group)
Am J Cardiol
(2006) - et al.
Doppler-derived mitral deceleration time as a strong prognostic marker of left ventricular remodeling and survival after acute myocardial infarction: results of the GISSI-3 echo substudy
J Am Coll Cardiol
(2004) - et al.
Plasma brain natriuretic peptide is a biochemical marker for the prediction of progressive ventricular remodeling after acute myocardial infarction
Am Heart J
(1998) - et al.
Left ventricular remodeling in the first year after acute myocardial infarction and the predictive value of N-terminal pro brain natriuretic peptide
Am Heart J
(2002) - et al.
Relation between plasma brain natriuretic peptide, serum indexes of collagen type I turnover, and left ventricular remodeling after reperfused acute myocardial infarction
Am J Cardiol
(2007) - et al.
Relation of plasma brain natriuretic peptide levels on admission for ST-elevation myocardial infarction to left ventricular end-diastolic volume six months later measured by both echocardiography and cardiac magnetic resonance
Am J Cardiol
(2009) - et al.
Plasma natriuretic peptides up to 2 years after acute myocardial infarction and relation to prognosis: an OPTIMAAL substudy
J Card Fail
(2005)
Cardiac magnetic resonance imaging study for quantification of infarct size comparing directly serial versus single time-point measurements of cardiac troponin T
J Am Coll Cardiol
Serum C-reactive protein elevation in left ventricular remodeling after acute myocardial infarction—role of neurohormones and cytokines
Int J Cardiol
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This study was supported by the CHRU de Lille PHRC 2005R/1901, Lille, the Fondation de France, Paris, and the Région Nord-Pas de Calais.