Heart failureComparison of Cardiac Power Output and Exercise Performance in Patients With Left Ventricular Assist Devices, Explanted (Recovered) Patients, and Those With Moderate to Severe Heart Failure
Section snippets
Methods
The study population consisted of 54 men who attended cardiopulmonary exercise testing at Harefield Hospital (Harefield, United Kingdom). Data were collected from August 2006 to May 2008. Exclusion criteria included inability to perform treadmill exercise tests, inability to exercise beyond anaerobic threshold, symptomatic angina limiting exercise, and unwillingness to provide a consent form. Of the 54 patients recruited, 20 had moderate to severe heart failure, 18 have implanted LVADs, and 16
Results
There were nonsignificant differences in age, body weight, and height in patients with moderate to severe heart failure, those with implanted LVADs, and those with explanted LVADs (p >0.05).
CPO at rest was not significantly different among groups with heart failure, implanted LVAD, and explanted LVAD (p >0.05). At peak exercise, CPO in patients with implanted LVADs and those with explanted LVADs was significantly higher compared to those with heart failure (p <0.01; Figure 1). Mean physiologic
Discussion
To our knowledge, the present study is the first to evaluate power-generating capacity of the heart in patients with implanted LVADs and those with explanted LVADs. The major findings of this study suggest that peak CPO and exercise performance were significantly higher in patients with explanted LVADs than in patients with moderate to severe heart failure and those with implanted LVADs.
Peak CPO and physiologic cardiac reserve of patients with explanted LVADs were similar to those in patients
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