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Usefulness of Relative Lymphocyte Count as an Independent Predictor of Death/Urgent Transplant in Heart Failure

https://doi.org/10.1016/j.amjcard.2005.02.022Get rights and content

The usefulness of low relative lymphocyte count as an independent predictor of death/urgent transplant in patients with heart failure (HF) and the association between low relative lymphocyte count and neurohormone and cytokine activation were investigated. Relative lymphocyte count, clinical variables, neurohormones, and cytokines were measured in 129 outpatients with HF. Follow-up extended to a mean of 3.0 ± 1.2 years for death/urgent transplant. Low relative lymphocyte count was independently associated with a 3.4-fold increased risk of death/urgent transplant. Relative lymphocyte count was positively associated with hemoglobin and inversely associated with age, jugular venous pressure, creatinine, leukocyte count, and soluble tumor necrosis factor receptor-1. There was only a borderline inverse association with cortisol levels during evening hours.

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This research was supported by a Charles A. Dana Foundation Grant, Dana Foundation, New York, New York; the American Heart Association, Dallas, Texas; and National Institutes of Health Grant M01-RR-0037 for the Clinical Research Center Facility at the University of Washington, Seattle, Washington. Dr. McDonald’s Cytokine Analysis Laboratory was supported by Grant CA18029 from the National Institutes of Health, Bethesda, Maryland.

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