Brief reportsUtility of cardiopulmonary stress testing in assessing disease severity in children with pulmonary arterial hypertension
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Cited by (43)
Exercise-Induced Electrocardiography Changes in Pulmonary Arterial Hypertension
2023, American Journal of CardiologyManagement of Pulmonary Hypertension in the Pediatric Patient
2022, Cardiology ClinicsCitation Excerpt :The 6-minute walk test is useful to assess functional capacity, monitor response to therapy, and predict outcomes. Using an actigraph, or a noninvasive monitor of patients' activity levels, provides a continuous real-time monitoring tool and is an attractive option for evaluating activity in patients with PH.35 Cardiopulmonary exercise testing is another testing modality that has been shown to provide cardiorespiratory parameters that correlate with the degree of pulmonary vascular resistance and disease severity in children36,37 and can reliably be performed in patients who are at least 7 years old. These tests are performed at 3- to 6-month intervals to guide response to therapy and indicate further interventions or escalation.
Pulmonary Hypertension in Children: A Global View
2021, Encyclopedia of Respiratory Medicine, Second EditionPediatric Pulmonary Arterial Hypertension
2020, Pediatric Clinics of North America35 - Childhood Pulmonary Arterial Hypertension
2019, Kendig's Disorders of the Respiratory Tract in ChildrenPulmonary Hypertension in Children
2016, Cardiology ClinicsCitation Excerpt :However, baseline 6MWD is not a predictor of survival, neither when expressed as an absolute distance in meters nor when adjusted to reference values expressed as z score or as percentage of predicted value.12,70 Cardiopulmonary exercise testing in children older than 7 years of age is useful to determine peak oxygen consumption, ventilator efficiency (VE) slope (Ve/VCO2), and anaerobic threshold.71,72 VE slope is significantly higher in patients with PAH, with an estimated increase of 7.2 for each increase in WHO class, and correlates strongly with invasive measures of disease severity, including PAP, PVRI, and outcome.73
This research study was supported by Grant M01 RR00069 from the General Research Centers Program, National Center for Research Resources, National Institutes of Health, Bethesda, Maryland.