Plasma brain natriuretic peptide in obstructive sleep apnea

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We compared brain natriuretic peptide (BNP) levels in patients with obstructive sleep apnea (OSA) with and without cardiovascular disease to BNP in healthy control subjects. OSA was not associated with increased plasma BNP or atrial natriuretic peptide (ANP) in otherwise healthy subjects during wakefulness. Untreated OSA increased ANP overnight, and ANP levels decreased with treatment of OSA. However, OSA did not elicit acute overnight changes in BNP, either in normal subjects or in patients with coexisting cardiovascular disease (including chronic heart failure).

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  • Interactions Between Sleep Disordered Breathing and Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy

    2010, American Journal of Cardiology
    Citation Excerpt :

    Our finding that the E/e′ ratio, a measurement of left ventricular filling pressures,25 is also increased in patients with SDB is consistent with previous studies and suggests that SDB may contribute to diastolic dysfunction,26 resulting in left atrial enlargement and increased risk for AF. Although increased filling pressures and impaired diastolic function may occur because of a thickened and noncompliant ventricular chamber27,28 due to HC, increased E/e′ ratio and elevated overnight atrial natriuretic peptide levels, reflecting increased left atrial pressure, have also been demonstrated in patients with SDB29,30 without HC. As listed in Table 1, the SDB group had a higher rate of treated hypertension, and this is consistent with the recognition of SDB as a cause of systemic hypertension.31

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This study was supported by Grants HL-65176, HL-61560, HL-70602, and M01-RR00585 from the National Institutes of Health, Bethesda, Maryland.

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