Clinical InvestigationHeart FailureAssociation between alcohol consumption and systolic ventricular function: A population-based study
Section snippets
Methods
The Olmsted County Heart Function Study was approved by the Mayo Foundation and Olmsted Medical Center Institutional Review boards, and written informed consent was obtained from the subjects. The present study was carried out with funding from US Public Health Services, National Institutes of Health, grant HL-RO1-555902. The authors are solely responsible for the design and conduct of this study, all study analyses, the drafting and editing of the paper, and its final contents.
Characteristics of study participants
Letters of invitations were sent to 4,203 individuals. Of the 2,042 individuals (48.6%) who participated, 1,916 (941 men and 975 women) had valid data and were included in the present analysis. The majority of participants were light drinkers (n = 1,028, 53.7%), with smaller proportions of abstainers (n = 182, 9.5%), former drinkers (n = 309, 16.1%), moderate drinkers (n = 251, 13.1%), and heavy drinkers (n = 146, 7.6%). Table I shows the baseline characteristics of participants categorized by
Principal findings
This population-based study demonstrated a U-shaped relationship between alcohol consumption and LV systolic function. In the Olmsted County Heart Study, the prevalence of moderate LV systolic dysfunction was the lowest in light drinkers (Table III, row 4; Figure 1), with the prevalence increasing with increasing or decreasing consumption of alcohol, indicating a U-shaped relationship. This relationship remained statistically significant for moderate systolic dysfunction even after adjustment
Conclusion
In a community setting, light alcohol consumption (<1 drink a day) was associated with a reduced prevalence of moderate systolic dysfunction (LVEF ≤40%).
Disclosures
Conflict of interests: The present study was carried out with funding from US Public Health Services, National Institutes of Health, grant HL-RO1-555902.
The authors have no competing interests to disclose.
Acknowledgements
The authors gratefully acknowledge Joe Grundle and Katie Klein for editorial preparation of the manuscript, Brian Miller and Brian Schurrer for their help in preparing figures, and Chi Cho for his help in creating the forest plot.
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Financial support: US Public Health Services, National Institutes of Health, HL-RO1-555902.