Clinical InvestigationPrevention and RehabilitationIndependent elevations of N-terminal pro–brain natriuretic peptide and cardiac troponins in endurance athletes after prolonged strenuous exercise
Section snippets
Study population
In total, 105 endurance athletes were examined at 3 endurance exercise events: a marathon (Mainz Marathon 2002, Germany), a 100-km ultramarathon (German Championship 2002), and a MTB marathon (St Wendel MTB-Marathon 2002, distance 110 km, altitude difference 2800 m). All randomly selected participants gave their written informed consent and filled in a questionnaire to register health status and cardiovascular risk factors (hypercholesterinemia, hypertension, familial predisposition of coronary
Results
Individual courses of NT-proBNP, cTnI, and cTnT of the participants are presented in Figure 1; median concentrations and exercise-induced changes of NT-proBNP, cTnI, and cTnT are presented in Figure 2.
Discussion
The results of the present study, which is the largest on exercise-induced alterations on NT-proBNP (or BNP) and cardiac troponins so far, indicate that prolonged strenuous exercise induces an increase in NT-proBNP, which is not related to the exercise-induced increases in cTnI or cTnT.
Although BNP or NT-proBNP have become hopeful markers in the diagnosis and treatment of patients with heart disease,1, 3, 6, 12, 13 the mechanisms leading to exercise-induced increases in BNP or NT-proBNP and
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The study was supported by a grant of the National Institute for Sports Sciences (Bundesinstitut für Sportwissenschaft: VF 0407/01/32/2002-2003), Bonn, Germany.